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KMID : 0390219990100020259
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Journal of Clinical Otolaryngology, Head and Neck Surgery
1999 Volume.10 No. 2 p.259 ~ p.263
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Tissue Reaction of Aldehyde-Tanned Collagen Sponges
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박문서/Moon Suh Park
김영수/오재국/김용복/이동훈/Young Soo Kim/Jae Kook Oh/Yong Bok Kim/Dong Hoon Lee
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Abstract
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Treating of the collagen material by chemical preservatives is a procedure to make a
homograft material in otologic surgery. Chemical treatment eliminates the antigenicity of
allo-or xenograft materials and enhances their physical strength for molding. To
evaluate the toxicity of chemical treatment through histological method, bovine collagen
sponges treated with 0.5% buffered glutaraldehyde or 4% formaldehyde solution. These
sponges were inserted into subcutaneous pockets of the rats and removed after 2 and 5
days. They were stained with hematoxilin-eosin and analyzed by light microsocopy.
Quantitative morphometry was done. Two days after implantation, the morphology
showed cellular reaction around the all rinsed collagen sponge. Inflammatory cells were
presented in the surface of the sponge. At five days artier implantation, more
pronounced cellular reactions were noticed around the rinsed sponge. Collagen sponge
without rinsing showed markedely melted architecture with inflammatory fell infiltration.
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